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Antioxidants help to counteract free radicals and protect the body from their damaging effects

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Because the oxidationreduction of Fe 2+ to Fe 3+ requires electron transfer, iron is involved in the electron migration between substrates ( 2+ or Fe 3+ ions and hydrogen peroxide (H 2 O 2 ) to produce highly reactive hydroxyl radicals ( 2+ is a cofactor of lipoxygenases (LOXs) that catalyzes PUFA-containing phospholipids into pro-ferroptotic lipid peroxidation (Yang et al., 2016)

Clinical studies show that vitamin C can significantly increase glutathione levels in red blood cells and lymphocytes

Toosendanin treatment reduces liver cell viability in a concentration-dependent manner